Para-selective gold-catalyzed direct alkynylation of anilines.
نویسندگان
چکیده
A method for the para-selective alkynylation of anilines is reported using AuCl as catalyst and triisopropylsilylethynyl-1,2-benziodoxol-3(1H)-one (TIPS-EBX) as an electrophilic acetylene equivalent. Para-alkynyl anilines substituted at positions 2 or 3 were obtained in one step from simple anilines under mild conditions (room temperature to 60 °C) under air. The methodology could also be extended to the alkynylation of trimethoxybenzenes.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2012